Germline HLA landscape does not predict efficacy of pembrolizumab monotherapy across solid tumor types
Aparna Chhibber, Lingkang Huang, Hong Zhang, Jialin Xu, Răzvan Cristescu, Xiao Liu, Devan V. Mehrotra, Judong Shen, Peter Shaw, Matthew D. Hellmann, Alexandra Snyder
Topics & Concepts
PembrolizumabLoss of heterozygosityGenotypingHuman leukocyte antigenBiologyGenotypeGermlineOncologyImmunologyInternal medicineGeneticsAntigenAlleleImmunotherapyImmune systemGeneMedicineCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesCancer Genomics and Diagnostics