Roles of lncRNA transcription as a novel regulator of chromosomal function
Satoshi Senmatsu, Kouji Hirota
Abstract
In recent years, many transcriptome analyses have revealed that numerous noncoding RNAs are transcribed in eukaryotic cells. Long noncoding RNAs (lncRNAs), which consist of over 200 nucleotides, are considered to be key players in a variety of biological processes and structures including gene expression, differentiation and nuclear architecture. Many studies on individual lncRNAs have identified their molecular functions as decoys, recruiters and scaffolds, which arise through interactions with proteins and the construction of ribonucleoproteins. In addition to the roles played by transcribed lncRNA molecules, several studies have indicated the important functions of nascent lncRNA transcription processes. In this review, we discuss recent findings on the important roles of lncRNA transcription processes in the regulation of chromosome function.