Identification of Anti-Mycobacterium and Anti-Legionella Compounds With Potential Distinctive Structural Scaffolds From an HD-PBL Using Phenotypic Screens in Amoebae Host Models
Nabil Hanna, Sébastien Kicka, Gianpaolo Chiriano, Christopher F. Harrison, Hajer Ouertatani Sakouhi, Valentin Trofimov, Agata Kranjc, Jahn Nitschke, Marco Pagni, Pierre Cosson, Hubert Hilbi, Léonardo Scapozza, Thierry Soldati
Abstract
drugs. Our studies underscore the relevance of using a combination of low-cost and low-complexity assays with full 3R compliance in concert with a rationalized focused library of compounds to identify new chemical scaffolds and to dissect some of their properties prior to taking further steps toward compound development.
Topics & Concepts
LegionellaHost (biology)BiologyIdentification (biology)MicrobiologyPhenotypeLegionella pneumophilaHost responseHost specificityComputational biologyBacteriaGeneticsGeneImmune systemEcologyLegionella and Acanthamoeba researchNeuroinflammation and Neurodegeneration MechanismsErythrocyte Function and Pathophysiology