The Clinical Significance of Urinary Retinol-Binding Protein 4: A Review
Krzysztof Ratajczyk, Andrzej Konieczny, Adrian Czekaj, Paweł Piotrów, Marek Fiutowski, Kornelia Krakowska, Paweł Kowal, Wojciech Witkiewicz, Karolina Marek-Bukowiec
Abstract
Effective biomarkers for early diagnosis, prognostication, and monitoring in renal diseases (in general) comprise an unmet need. Urinary retinol-binding protein 4, which is the most sensitive indicator of renal tubular damage, holds great promise as a universal biomarker for renal pathologies, in which tubular injury is the driving force. Here, we summarize the most important existing data on the associations between urinary retinol-binding protein 4 and renal diseases and highlight the untapped potential of retinol-binding protein 4 in clinical use.
Topics & Concepts
Retinol binding proteinBiomarkerUrinary systemMedicineRetinol binding protein 4RetinolInternal medicineChemistryBiochemistryVitaminInsulin resistanceInsulinAdipokineRetinal Diseases and TreatmentsRetinoids in leukemia and cellular processesNeonatal Health and Biochemistry