T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting
Christopher J. Hanley, Gareth J. Thomas
Abstract
Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in promoting immunotherapy resistance by excluding T cells from tumours. Recently, we showed that CAFs can be effectively targeted by inhibiting the enzyme NOX4; this 'normalises' CAFs and overcomes immunotherapy resistance. Here we discuss our study and other strategies for CAF targeting.
Topics & Concepts
ImmunotherapyCancer researchMedicineImmunologyImmune systemCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesCAR-T cell therapy research