Synthesis of substituted pyrimidine using <scp>ZnFe<sub>2</sub>O<sub>4</sub></scp> nanocatalyst via one pot multi‐component reaction ultrasonic irradiation
Pravin Chavan, Sachin Bangale, Dattatraya N. Pansare, Rohini N. Shelke, Shivaji Jadhav, Shrikrushna Tupare, Dhanraj Kamble, Megha Rai
Abstract
Abstract A highly efficient, eco‐friendly, recyclable heterogeneous ZnFe 2 O 4 nanocatalyzed synthesis of 2‐amino‐4‐substituted 1,4‐dihydrobenzo[4,5]imidazo[1,2‐a]pyrimidine‐3‐carbonitrile (4a‐j) derivatives via one pot multicomponent reaction of benzimidazole ( 1 ), substituted aromatic aldehyde ( 2a‐j ) and malononitrile ( 3 ) under ultrasonic irradiations. Significance of this synthetic approach is short reaction time, easy handling, simplicity, efficiency, high yield, and recoverable catalyst.
Topics & Concepts
ChemistryMalononitrileAldehydeYield (engineering)BenzimidazolePyrimidineCatalysisOne-pot synthesisCombinatorial chemistryEnvironmentally friendlyReaction conditionsComponent (thermodynamics)Organic chemistryStereochemistryThermodynamicsBiologyPhysicsMaterials scienceMetallurgyEcologyMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds