Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity
Joshua D Garcia, Sara E. Gookin, Kevin C. Crosby, Samantha L. Schwartz, Erika Tiemeier, Matthew J. Kennedy, Mark L. Dell’Acqua, Paco S. Herson, Nidia Quillinan, Katharine R. Smith
Abstract
R nanoscale reorganization and synaptic declustering depends on calcineurin signaling, whereas disassembly of gephyrin relies on calpain activation, and blockade of both enzymes preserves inhibitory synapses after excitotoxic insult. Thus, inhibitory synapse disassembly occurs rapidly, with nanoscale precision, in a stepwise manner and most likely represents a critical step in the progression of hyperexcitability following excitotoxicity.
Topics & Concepts
GABAergicExcitotoxicityNeuroscienceBiologyChemistryGlutamate receptorBiochemistryReceptorInhibitory postsynaptic potentialNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neural Engineering