Anti-Alzheimer chemical constituents of <i>Morus macroura</i> Miq.: chemical profiling, <i>in silico</i> and <i>in vitro</i> investigations
Seham S. El‐Hawary, Ahmed M. Sayed, Marwa Y. Issa, Hanaa S. Ebrahim, Rania Alaaeldin, Mahmoud A. Elrehany, Essam M. Abd El-Kadder, Usama Ramadan Abdelmohsen
Abstract
values comparable with those of the reference inhibitors. Additionally, they were able to inhibit the aggregation of amyloid-beta, one of the hallmarks in AD pathogenesis, and to exhibit considerable antioxidant capacity. Our results highlighted Morus macroura compounds as future anti-Alzheimer chemical leads.
Topics & Concepts
ChemistryIn silicoIn vitroPharmacophoreChrysinFerulic acidBiochemistryDocking (animal)AntioxidantGeneMedicineFlavonoidNursingMedicinal Plants and NeuroprotectionCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatments