Enantioselective Nickel‐Catalyzed C(sp<sup>3</sup>)−H Activation of Formamides
Yin‐Xia Wang, Feng‐Ping Zhang, Hao Chen, Yue Li, Jiang‐Fei Li, Mengchun Ye
Abstract
Abstract Enantioselective Ni‐catalyzed C(sp 3 )−H bond activation remains an elusive challenge. Herein, we used phosphine oxide‐ligated Ni−Al bimetallic catalyst to realize enantioselective Ni‐catalyzed aliphatic C(sp 3 )−H activation of formamides, providing a series of chiral N‐containing heterocycles in 40–95 % yield and 70–95 % ee.
Topics & Concepts
Enantioselective synthesisFormamidesNickelCatalysisChemistryMedicinal chemistryStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis