Human interleukin-4–treated regulatory macrophages promote epithelial wound healing and reduce colitis in a mouse model
Timothy S. Jayme, Gabriella Leung, Arthur Wang, Matthew L. Workentine, Sruthi Rajeev, Adam Shute, Blanca E. Callejas, Nicole L. Mancini, Paul L. Beck, Remo Panaccione, Derek M. McKay
Abstract
mice significantly reduced disease. These findings from in vitro and in vivo analyses provide proof-of-concept support for the development of autologous M(IL4) transfer as a cellular immunotherapy for IBD.
Topics & Concepts
ColitisWound healingImmunologyInterleukinInflammationMedicineMicrobiologyBiologyCytokineImmune cells in cancerIL-33, ST2, and ILC PathwaysImmune Response and Inflammation