Development of 8–17 XNAzymes that are functional in cells
Kosuke Chiba, Takao Yamaguchi, Satoshi Obika
Abstract
Modified 8–17 DNAzymes that can induce target gene silencing in cells were developed based on the X-ray crystal structure of 8–17 DNAzyme and the modifications used in designing antisense oligonucleotides.
Topics & Concepts
DeoxyribozymeNucleic acidOligonucleotideRNACleaveDNAChemistryCleavage (geology)Gene knockdownNucleic acid structureComputational biologyBiochemistryMolecular biologyCell biologyBiologyGeneFracture (geology)PaleontologyAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms