Photoactivated Hydrogen Sulfide Donor with a Near-Infrared Fluorescence Report System for Accelerated Chronic Wound Healing
Fang Yuan, Xiaomeng He, Yurong Lu, Lulu Ning, Xinyue Zhao, Suya Zhang, Feng Guan, Yuan Guo, Jianjian Zhang
Abstract
Delayed wound healing is one of the major diabetes complications that occur in 25% of diabetic patients. Specific wound management and combination treatment are required to repair the wound, which still remains a challenge with few effective therapies available currently. In this work, a new H 2 S donor PRO-F, which is characterized by the capability to promote wound healing in diabetes, was designed. PRO-F can be activated by light without consuming endogenous substances and the accompanying fluorescent signal makes the real-time tracking of released H 2 S possible. PRO-F is able to deliver H 2 S in an intracellular environment with moderate release efficiency (50%), which presents cytoprotective effects against excessive reactive oxygen species (ROS) induced damage. Furthermore, the potential of PRO-F to enhance chronic wound healing was validated by employing diabetic models. This work provides new insights into the therapeutic role of H 2 S donors in complex wound conditions, which should advance the pathophysiological research associated with H 2 S.