Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models
Ayako Nakayama, Takeyuki Nagashima, Yoshihiro Nishizono, Kazuyuki Kuramoto, Kenichi Mori, Kazuya Homboh, Masatoshi Yuri, Masashi Shimazaki
Topics & Concepts
KRASIn vivoCancer researchIn vitroPharmacologyCancerCancer cellMedicineChemistryBiologyColorectal cancerInternal medicineBiochemistryBiotechnologyProtein Kinase Regulation and GTPase SignalingReceptor Mechanisms and SignalingPI3K/AKT/mTOR signaling in cancer