Metal–organic framework MIL-101(Fe) functionalized with folic acid as a multifunctional nanocarrier for targeted chemotherapy–photodynamic therapy
Eman Serag, Esmail M. El‐Fakharany, Sherif Hammad, Mohamed E. El‐Khouly
Abstract
doses under both dark and light conditions indicates that the primary mechanism of cell death is necrosis, likely due to the enhanced formation of reactive oxygen species (ROS) under light conditions compared to that under dark conditions. This increased reactive oxygen species (ROS) generation leads to extensive membrane rupture, resulting in significant cell damage after treatment with the modified MIL-101-FA@50% DO8 NPs. These findings underscore the potential of this nanocomposite as an effective PDT agent for targeted cancer therapy.
Topics & Concepts
NanocarriersPhotodynamic therapyFolic acidChemistryMetal-organic frameworkConjugated systemMetalCancer researchCombinatorial chemistryNanotechnologyMedicineMaterials scienceOrganic chemistryDrug deliveryInternal medicineAdsorptionPolymerMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsAdvanced Photocatalysis Techniques