Case Report: Management of Recurrent Ovarian Squamous Cell Carcinoma With PD-1 Inhibitor
Xiaochen Song, Yongxue Wang, Mei Yu, Dongyan Cao, Jiaxin Yang
Abstract
Malignant transformations, such as ovarian squamous cell carcinoma (SCC) in ovarian mature cystic teratoma (OMCT), are rare tumors. The management of recurrent disease is still a challenge, and the gene mutations involved remain unclear. We herein report a recurrent case of ovarian SCC with a PIK3CA gene variation and immunohistochemical staining of programmed death-ligand 1 (PD-L1) >10%. This patient achieved clinical remission after platinum-based effective chemotherapy and programmed death 1 (PD-1) immunotherapy.
Topics & Concepts
ImmunotherapyMedicineImmunohistochemistryOvarian carcinomaChemotherapyEpithelial ovarian carcinomaOvarian cancerOncologyCancer researchPD-L1PathologyInternal medicineCancerOvarian cancer diagnosis and treatmentNeuroendocrine Tumor Research AdvancesCancer Immunotherapy and Biomarkers