Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement
Ling Li, Shiqi Zhang, Xiongfei Deng, Guangxun Li, Zhuo Tang, Gang Zhao
Abstract
α-Imino ketone is a useful building block for the preparation of α-amino ketones and α-amino alcohols. However, its preparation has been seldomly seen. Herein, a metal-free and operationally simple strategy has been developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.
Topics & Concepts
ChemistryRegioselectivityKetoneTandemCombinatorial chemistryCascade reactionCascadeOrganic chemistryCatalysisChromatographyComposite materialMaterials scienceSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis