Csp<sup>3</sup>–H monofluoroalkenylation <i>via</i> stereoselective C–F bond cleavage
Ying Hu, Xingchen Liu, Zhouyang Ren, Binjing Hu, Jie Li
Abstract
A practical nickel- and photoredox-catalyzed Csp 3 –H monofluoroalkenylation with gem -difluoroalkenes for the synthesis of stereodefined tetrasubstituted fluoroalkenes with complete control of stereoselectivity has been developed.
Topics & Concepts
ChemistryStereoselectivityCleavage (geology)Bond cleavageChelationCombinatorial chemistryPhotoredox catalysisCascadeCatalysisStereochemistryMedicinal chemistryOrganic chemistryPhotocatalysisMaterials scienceComposite materialChromatographyFracture (geology)Fluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods