RhoA within myofibers controls satellite cell microenvironment to allow hypertrophic growth
Chiara Noviello, Kassandra Kobon, Léa Delivry, Thomas Guilbert, Florian Britto, Francis Julienne, Pascal Maire, Voahangy Randrianarison-Huetz, Athanassia Sotiropoulos
Abstract
Their decreased expression in RhoA mutants is associated with ECM and fibrillar collagen disorganization and lower macrophage infiltration. Moreover, matrix metalloproteinases inhibition and macrophage depletion in controls phenocopied the altered growth of RhoA mutants while having no effect in mutants showing that their action is RhoA-dependent. These findings unravel the implication of RhoA within myofibers, in the building of a permissive microenvironment for muscle hypertrophic growth and for SC accretion through ECM remodeling and inflammatory cell recruitment.
Topics & Concepts
RHOACell biologyExtracellular matrixCCL3ChemistryCell growthBiologyChemokineSignal transductionInflammationImmunologyBiochemistryCCL2Muscle Physiology and DisordersTissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical Applications