Visible-Light-Promoted Hydroxydifluoroalkylation of Alkenes Enabled by Electron Donor–Acceptor Complex
Zhenzhen Xie, Yu Zheng, Kai Tang, Jianping Guan, Chu‐Ping Yuan, Jun‐An Xiao, Hao‐Yue Xiang, Kai Chen, Xiaoqing Chen, Hua Yang
Abstract
A catalyst-free strategy for regioselective hydroxydifluoroalkylation of alkenes with alkyl bromides was developed, affording a series of difluoroalkylated tertiary alcohols in moderate to good yields. This photocatalyst-free protocol shows broad substrate scope under mild conditions. Moreover, mechanistic studies revealed that a newly identified electron donor-acceptor complex is crucial to this transformation.
Topics & Concepts
ChemistryRegioselectivityCatalysisElectron donorAcceptorElectron acceptorAlkylSubstrate (aquarium)PhotochemistryCombinatorial chemistryPhotocatalysisVisible spectrumOrganic chemistryPhysicsCondensed matter physicsOceanographyOptoelectronicsGeologyFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods