Rational downstream development for adeno-associated virus full/empty capsid separation – A streamlined methodology based on high-throughput screening and mechanistic modeling
William R. Keller, Angela L. Picciano, Kelly G. Wilson, Jin Xu, Harshit Khasa, Michaela Wendeler
Topics & Concepts
CapsidDownstream processingElutionChromatographyChemistryAdeno-associated virusHigh-throughput screeningRecombinant DNAVector (molecular biology)GeneBiochemistryVirus-based gene therapy researchCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in Insects