Pd-catalysed β-selective C(sp<sup>3</sup>)–H arylation of simple amides
Hong‐Yan Hao, Shao‐Jie Lou, Shuang Wang, Kun Zhou, Qiuzi Wu, Yang‐Jie Mao, Zhenyuan Xu, Dan‐Qian Xu
Abstract
)-H arylation of diverse native amides with aryl iodides was developed. This protocol overcomes the necessity of the Thorpe-Ingold effect and features broad substrate scope and good functional group tolerance. The potential application of this protocol is collectively demonstrated by gram-scale synthesis and the synthesis of several bioactive molecules.
Topics & Concepts
ChemistrySimple (philosophy)Combinatorial chemistryCatalysisMedicinal chemistryOrganic chemistryEpistemologyPhilosophyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis