The emerging roles of non-canonical ubiquitination in proteostasis and beyond
Yoshino Akizuki, Stephanie Kaypee, Fumiaki Ohtake, Fumiyo Ikeda
Abstract
Ubiquitin regulates various cellular functions by posttranslationally modifying substrates with diverse ubiquitin codes. Recent discoveries of new ubiquitin chain topologies, types of bonds, and non-protein substrates have substantially expanded the complexity of the ubiquitin code. Here, we describe the ubiquitin system covering the basic principles and recent discoveries related to mechanisms, technologies, and biological importance.
Topics & Concepts
UbiquitinProteostasisUbiquitin-Protein LigasesComputational biologyUbiquitin ligaseBiologyCell biologyBiochemistryGeneUbiquitin and proteasome pathwaysProtein Degradation and InhibitorsAutophagy in Disease and Therapy