A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment
Jesko Kaiser, Christoph G. W. Gertzen, Tamara Bernauer, Georg Höfner, Karin V. Niessen, Thomas Seeger, Franz F. Paintner, Klaus T. Wanner, Franz Worek, Horst Thiermann, Holger Gohlke
Topics & Concepts
Allosteric regulationChemistryBinding siteNicotinic agonistNicotinic acetylcholine receptorDocking (animal)AcetylcholineBiophysicsPharmacologyReceptorBiochemistryBiologyMedicineNursingInsect and Pesticide ResearchIon channel regulation and functionSynthesis and Biological Evaluation