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A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy

Dulguun Amgalan, Thomas P. Garner, Ryan Pekson, Xiaotong F. Jia, Mounica Yanamandala, Victor M. Paulino, Felix G. Liang, J. Jose Corbalan, Jaehoon Lee, Yun Chen, George S. Karagiannis, Luis Rivera Sanchez, Huizhi Liang, Swathi-Rao Narayanagari, Kelly Mitchell, Andrea López, Victoria Margulets, Marco Scarlata, Gaetano Santulli, Aarti Asnani, Randall T. Peterson, Rachel B. Hazan, John S. Condeelis, Maja H. Oktay, Ulrich Steidl, Lorrie A. Kirshenbaum, Evripidis Gavathiotis, Richard N. Kitsis

2020Nature Cancer125 citationsDOIOpen Access PDF

Topics & Concepts

DoxorubicinAllosteric regulationSmall moleculeChemistryCardiomyopathyPharmacologyCancer researchMedicineBiochemistryInternal medicineHeart failureEnzymeChemotherapyChemotherapy-induced cardiotoxicity and mitigationElectron Spin Resonance StudiesCoenzyme Q10 studies and effects
A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy | Litcius