Developing point-of-care diagnosis using electrochemical biosensor: Mosquito-borne disease
Muhammad Fadlan Raihan, Ni Luh Wulan Septiani, Gilang Gumilar, Robeth Viktoria Manurung, Siti Nurul Aisyiyah Jenie, Ahmad Nuruddin, Brian Yuliarto
Abstract
• Review on recent progress in electrochemical biosensors for mosquito-borne diseases. • The pathogens focused on Dengue, Zika, Chikungunya, and Malaria parasite. • Comprehensive review on POC biosensors for mosquito-borne diseases. • Future potential of POC biosensors for mosquito-borne diseases are discussed. Mosquito-borne diseases continue to pose a significant threat to global health, encompassing a wide range of illnesses caused by pathogens transmitted by mosquito vectors, including viruses, bacteria, and parasites. Diseases such as malaria, dengue, chikungunya, and Zika underscore the urgent need for effective detection methods, along with appropriate preventive measures to mitigate their severity. In response, electrochemical-based biosensor technologies have emerged as a promising solution for rapid, sensitive, and specific diagnosis. This review comprehensively examines recent advances in the utilization of biorecognition elements in electrochemical biosensor systems for detecting mosquito-borne diseases. The discussion covers an overview of the biorecognition elements employed, diagnostic performance assessments, design considerations, and their potential as point-of-care (POC) biosensors. By synthesizing these developments, this review emphasizes the critical role of electrochemical biosensors in advancing global health initiatives against mosquito-borne diseases. Finally, the discussion also addresses the future prospects of POC features in diagnosing these diseases.