Ru(<scp>ii</scp>)-catalyzed regioselective [4 + 1] redox-neutral spirocyclization of aryl amidines with diazopyrazolones: direct access to spiro[indole-3,4′-pyrazol]-5′-ones
Bo Cui, Jian Shen, Yadong Feng, Shenghui Lin, Xiuling Cui
Abstract
An efficient protocol to construct spiro[indole-3,4′-pyrazol]-5′-ones via ruthenium( ii )-catalyzed selective C–H bond activation/[4 + 1] spirocyclization starting from easily available N -aryl amidines and diazopyrazolones has been developed.
Topics & Concepts
ChemistryIndole testRegioselectivityRutheniumArylCatalysisCombinatorial chemistryRedoxMedicinal chemistryStereochemistryOrganic chemistryAlkylCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions