The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2
Megan E. Arrington, Brenda Temple, Antje Schaefer, Sharon L. Campbell
Abstract
mutation promotes immune dysfunction by promoting RAC2 hyperactivation, altering GEF specificity, and impairing GAP function yet retaining key effector interactions.
Topics & Concepts
Guanine nucleotide exchange factorEffectorGTPaseCell biologyRac GTP-Binding ProteinsMutationBiologySmall GTPaseMutantGTPase-activating proteinSignal transductionChemistryGeneticsRAC1G proteinGeneErythrocyte Function and PathophysiologyImmunodeficiency and Autoimmune DisordersAdenosine and Purinergic Signaling