A cyanosulfidic origin of the Krebs cycle
Dougal J. Ritson
Abstract
), which leads to α-oxo carboxylates that feature in the Krebs cycle and glyoxylate shunt. Further reaction of these products leads to almost all intermediates of the Krebs cycle proper, succinate semialdehyde bypass, and glyoxylate shunt. Fumarate, the missing Krebs cycle component, and the required α-hydroxy carboxylates can be provided by a highly related hydrogen cyanide chemistry, which also provides precursors for amino acids, nucleotides, and phospholipids.
Topics & Concepts
PrebioticComputational biologyCitric acid cycleBiologyComputer scienceAstrobiologyChemistryBiochemistryMetabolismOrigins and Evolution of LifePhotoreceptor and optogenetics researchPhotosynthetic Processes and Mechanisms