Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition
Gourish Mondal, Julieann C. Lee, Ajay Ravindranathan, Javier Villanueva-Meyer, Quynh T. Tran, Sariah J. Allen, Jairo Barreto, Rohit Gupta, Pamela Doo, Jessica Van Ziffle, Courtney Onodera, Patrick Devine, James P. Grenert, David Samuel, Rong Li, Laura K. Metrock, Lee‐Way Jin, Reuben Antony, Mouied Alashari, Samuel Cheshier, Nicholas Whipple, Carol S. Bruggers, Corey Raffel, Nalin Gupta, Cassie Kline, Alyssa Reddy, Anu Banerjee, Matthew D. Hall, Minesh P. Mehta, Ziad Khatib, Ossama Maher, Carole Brathwaite, Melike Pekmezci, Joanna J. Phillips, Andrew W. Bollen, Tarık Tihan, John T. Lucas, Alberto Broniscer, Mitchel S. Berger, Arie Perry, Brent A. Orr, David A. Solomon
Topics & Concepts
ExonBiologyProtein kinase domainMissense mutationCancer researchTyrosine kinaseMutationGeneticsGeneSignal transductionMutantGlioma Diagnosis and TreatmentChromatin Remodeling and CancerEpigenetics and DNA Methylation