Recent advances in understanding the role of HES6 in cancers
Imène Krossa, Thomas Strub, Arnaud Martel, Sacha Nahon‐Estève, Sandra Lassalle, Paul Hofman, Stéphanie Baillif, Robert Ballotti, Corine Bertolotto
Abstract
The NOTCH signaling system regulates a variety of cellular processes during embryonic development and homeostasis maintenance in different tissues and contexts. Hence, dysregulation of NOTCH signaling is associated with a plethora of human cancers, and there have been multiple efforts to target key components of this pathway. In this review, we briefly highlight the latest research advances in understanding HES6, a poorly studied component of the NOTCH pathway. We summarize the role of HES6 in cancers with a focus on uveal melanoma. Finally, we discuss the ongoing efforts to target the NOTCH-HES6 axis in cancers.