Stability analysis of five-grade Leishmania epidemic model with harmonic mean-type incidence rate
Karim M. Khan, Rahat Zarin, Amir Khan, Abdullahi Yusuf, M. M. Al-Shomrani, Arif Ullah
Abstract
Abstract In this paper, we discuss the Anthroponotic Cutaneous Leishmania transmission. In addition, we develop a mathematical model for the Anthroponotic Cutaneous Leishmania transmission and consider its qualitative behavior. We derive the threshold number $R_{0}$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mi>R</mml:mi> <mml:mn>0</mml:mn> </mml:msub> </mml:math> of the model using the next generation method. In the disease-free case, we carry out the local and global stability under the condition $R_{0}<1$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mi>R</mml:mi> <mml:mn>0</mml:mn> </mml:msub> <mml:mo><</mml:mo> <mml:mn>1</mml:mn> </mml:math> . Moreover, we derive the global stability at the disease-free equilibrium point by utilizing the Castillo-Chavez method. On the other hand, at the endemic equilibrium point, we show the local and global stability to be held under specific conditions and $R_{0}>1$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mi>R</mml:mi> <mml:mn>0</mml:mn> </mml:msub> <mml:mo>></mml:mo> <mml:mn>1</mml:mn> </mml:math> . We also establish the global stability at the endemic equilibrium point with the help of a geometrical approach, which is a generalization of Lyapunov theory, by using a second additive compound matrix. Finally, we take into account the sensitivity analysis of the threshold number with other parameters. We also discuss several graphs of important parameters.