Biosynthesized iron oxide-nanoparticle encapsulated hydrogel functionalized with platelet-rich plasma (PRP) accelerates wound healing in an animal model
Lipsa Leena Panigrahi, Siddharth Satpathy, Pallavi Samal, Shashank Shekhar, Shakti Ketan Prusty, Manoranjan Arakha
Abstract
green-synthesized IONP incorporation, illustrating more pronounced killing in Gram-negative bacteria, which is highly consistent with TEM-morphological alterations in the bacteria's structure, cell wall, and membrane. The chitosan-based hydrogel exhibited the lowest half-maximal scavenging concentration. The hydrogels also exhibited high cell viability and growth. Further investigation into the wound healing activity of the hydrogel was conducted using an animal model, which showed healing in 18 days compared to the control and standard. Overall, this study demonstrates a feasible design for tailoring new surface-functionalized organic-inorganic hybrid hydrogels as promising antimicrobial and wound healing agents.