Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping
John O. Miners, Andrew Rowland, Jonathan J. Novak, Kimberly Lapham, Theunis C. Goosen
Topics & Concepts
GlucuronidationDrug metabolismDrugEnzymePharmacologyGlucuronosyltransferaseMicrosomeChemistryBiochemistryIn vitroDrug developmentBiologyPharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsDrug-Induced Hepatotoxicity and Protection