Preliminary Characterization of NP339, a Novel Polyarginine Peptide with Broad Antifungal Activity
Vanessa Duncan, Daniel Smith, Laura Simpson, Emma Lovie, Laura Katvars, Leon Berge, Jennifer Robertson, Shane Smith, Carol Munro, Derry Mercer, Deborah O’Neil
Abstract
. Preliminary analyses in murine models indicate scope for therapeutic application of NP339 against a range of systemic and mucocutaneous fungal infections. Collectively, these data indicate that NP339 can be developed into a highly differentiated, first-in-class antifungal candidate for poorly served invasive and other serious fungal diseases.
Topics & Concepts
PeptideAntifungalBiologyMicrobiologyFungicideImmune systemToxicityFluconazoleIn vitroComputational biologyBiochemistryChemistryAcquired resistanceCell membraneItraconazoleEchinocandinsMucocutaneous zoneFungal proteinIn vivoAntimicrobial peptidesPharmacologyBiological activityAntimicrobial Peptides and ActivitiesAntimicrobial agents and applicationsMicrobial Natural Products and Biosynthesis