Novel dual methylation of cytidines in the RNA of mammals
Mingyu Cheng, Xue‐Jiao You, Jiang-Hui Ding, Yi Dai, Mengyuan Chen, Bi‐Feng Yuan, Yu‐Qi Feng
Abstract
We synthesized 3,2′-<italic>O</italic>-dimethylcytidine (m<sup>3</sup>Cm) and determined the dimethylation of cytidines in mammals by mass spectrometry analysis. We discovered m<sup>3</sup>Cm in small RNA and <italic>N</italic>4,2′-<italic>O</italic>-dimethylcytidine (m<sup>4</sup>Cm) in 18S rRNA of mammals.
Topics & Concepts
RNAMethylationBiologyDNAMolecular biologyGeneticsChemistryGeneRNA modifications and cancerCancer-related gene regulationEpigenetics and DNA Methylation