Lysosome- and plasma membrane-accumulative and tumor-targetable polythiophene nanoparticles for enhanced sonodynamic therapy
E Pang, Xuejian Xing, Shaojing Zhao, Qiuxia Tan, Tangna Pan, Ting Yu, Yabing Gan, Benhua Wang, Siyi Tan, Yi Zhang, Peng Yin, Xiangzhi Song, Minhuan Lan
Abstract
experimental results demonstrated that PDPF NPs could induce cancer-cell death through apoptosis and necrosis, inhibit DNA replication, and ultimately achieve tumor depletion upon US irradiation. These findings revealed that polythiophene could serve as an efficacious sonosensitizer for enhanced US treatment of deep-seated tumors.
Topics & Concepts
PolythiopheneSonodynamic therapyLysosomeMaterials sciencePlasmaNanoparticleMembraneCancer researchNanotechnologyMedicineConductive polymerChemistryBiochemistryPolymerComposite materialUltrasoundRadiologyEnzymeQuantum mechanicsPhysicsNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsNanoparticle-Based Drug Delivery