Schisantherin A ameliorates liver fibrosis through TGF-β1mediated activation of TAK1/MAPK and NF-κB pathways in vitro and in vivo
Haili Wang, Jin-Ying Che, Kai Cui, Wenyue Zhuang, He Li, Jinghui Sun, Jianguang Chen, Chunmei Wang
Topics & Concepts
Hepatic stellate cellMAPK/ERK pathwayAspartate transaminaseTransforming growth factorThioacetamideFibrosisSirius RedTumor necrosis factor alphaHepatic fibrosisPathologyCancer researchMedicineChemistryKinaseInternal medicineBiochemistryAlkaline phosphataseEnzymePlant-derived Lignans Synthesis and BioactivityDrug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology