The 5-HT <sub>3</sub> Receptor Affects Rotavirus-Induced Motility
Marie Hagbom, Arash Hellysaz, Claudia Istrate, Johan Nordgren, Sumit Sharma, Felipe Meira de-Faria, Karl-Eric Magnusson, Lennart Svensson
Abstract
The mechanisms underlying rotavirus-induced diarrhea and vomiting are not yet fully understood. To better understand rotavirus pathophysiology, characterization of nerve signaling within the ENS and through vagal efferent nerves to the brain, which have been shown to be of great importance to the disease, is necessary.
Topics & Concepts
BiologyUssing chamberReceptorMotilityInternal medicineDiarrheaVomitingEndocrinologyReceptor antagonistReceptor expressionEnteric nervous systemImmunologyGhrelinFluorescein isothiocyanateIntestinal mucosaInterstitial cell of CajalCholecystokininVagus nerveSubstance PRotavirusSmall intestineTRPV1Viral gastroenteritis research and epidemiologyGastrointestinal motility and disordersAdvanced Chemical Sensor Technologies