Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy
Qi Zhan, Kaikai Yi, Hongzhao Qi, Sidi Li, Xueping Li, Qixue Wang, Yunfei Wang, Chaoyong Liu, Mingzhe Qiu, Xubo Yuan, Jin Zhao, Xin Hou, Chunsheng Kang
Abstract
This study demonstrates the potential of engineered blood exosomes as feasible co-delivery nanosystem for tumor-targeted and efficient combination therapy. Further development by replacing the drugs combined regimens can potentially make this engineered exosome become a general platform for the design of safe and effective combination therapy modality.
Topics & Concepts
MicrovesiclesGenetic enhancementCancer researchMedicineGeneChemistrymicroRNABiochemistryExtracellular vesicles in diseaseRNA Interference and Gene DeliveryMicroRNA in disease regulation