Amide bond hydrolysis of peptoids
Pritam Ghosh, Guilin Ruan, Natalia Fridman, Galia Maayan
Abstract
Incorporating a chiral non-coordinating substitution at the N-terminal end within peptoids facilitates regio-selective amide bond hydrolysis mediated by a transition metal ion and/or an acidic buffer as evident by X-ray crystallographic analysis, supported by ESI-MS. This opens up a new direction for peptidomimetic compounds towards future application in chemistry, biology and medicine.
Topics & Concepts
PeptidomimeticAmidePeptide bondHydrolysisChemistryCombinatorial chemistryStereochemistryOrganic chemistryPeptideBiochemistryEnzymeChemical Synthesis and AnalysisMass Spectrometry Techniques and ApplicationsBiochemical and Structural Characterization