Involvement of the Iron-Regulated Loci <i>hts</i> and <i>fhuC</i> in Biofilm Formation and Survival of Staphylococcus epidermidis within the Host
Fernando Oliveira, Tânia Lima, Alexandra Correia, Ana Margarida Silva, Cristina Soares, Simone Morais, Samira Weißelberg, Manuel Vilanova, Holger Rohde, Nuno Cerca
Abstract
in biofilm formation under host relevant conditions and, most importantly, in survival within the host. Ultimately, these findings highlight iron acquisition and these loci in particular, as potential targets for future therapeutic strategies against biofilm-associated S. epidermidis infections.
Topics & Concepts
Staphylococcus epidermidisBiofilmBiologyMicrobiologyPathogenImmune systemBacteriaPhenotypeGeneticsStaphylococcus aureusHuman pathogenHost (biology)Staphylococcal infectionsBacterial geneticsGeneStaphylococcusMicrococcaceaeCellBacteremiaBloodstream infectionImmunologyBacterial biofilms and quorum sensingAntimicrobial Resistance in StaphylococcusBacterial Genetics and Biotechnology