COVID-19 and the endothelium
F. Jung, Anne Krüger‐Genge, R.P. Franke, F. Hufert, J.‐H. Küpper
Abstract
There is growing evidence that COVID-19 not only affects the lungs but beyond that the endothelial system. Recent studies showed that this can lead to microcirculatory impairments and in consequence to functional disorders of all inner organs. The combination of endothelial dysfunction with a generalized inflammatory state and complement elements may together contribute to the overall pro-coagulative state described in COVID-19 patients leading to venular as well as to arteriolar occlusions.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)EndotheliumVirologyPandemicMedicineCoronavirus InfectionsBetacoronavirusInternal medicineInfectious disease (medical specialty)OutbreakDiseaseCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19Thermal Regulation in Medicine