Dendritic polyglycerolsulfate-SS-poly(ester amide) micelles for the systemic delivery of docetaxel: pushing the limits of stability through the insertion of π–π interactions
Daniel Braatz, Justus H. Peter, Mathias Dimde, Elisa Quaas, Kai Ludwig, Katharina Achazi, Michael Schirner, Matthias Ballauff, Rainer Haag
Abstract
) efficiently reduced to 68 nM coming along with high viabilities of the empty polymer materials tested on tumor-derived HeLa, A549, and McF-7 cell lines after two days. This study highlights the substantial potential of micelles tailored through the combination of π-electron stabilization with dendritic polyglycerolsulfate for targeted drug delivery systems, enabling them to have a significant foothold in the clinical treatment of cancer.
Topics & Concepts
MicelleDynamic light scatteringMaterials scienceCopolymerAmphiphileDrug deliveryChemical engineeringPolymer chemistryNuclear chemistryChemistryOrganic chemistryNanoparticleNanotechnologyAqueous solutionPolymerComposite materialEngineeringNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched PolymersRNA Interference and Gene Delivery