Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease
Matthew Bratkowski, Thomas C. Burdett, Jean Danao, Xidao Wang, Prakhyat Mathur, Weijing Gu, Jennifer A. Beckstead, Santosh Talreja, Yu-San Yang, Gregory Danko, Jae Hong Park, Mary Walton, Sean P. Brown, Christopher M. Tegley, Prem Raj B. Joseph, Charles H. Reynolds, Shilpa Sambashivan
Topics & Concepts
NeuroprotectionNAD+ kinaseNicotinamide adenine dinucleotideCD38PharmacologyNeuroscienceBiochemistrySmall moleculeBiologyChemistryEnzymeCell biologyCD34Stem cellCalcium signaling and nucleotide metabolismSignaling Pathways in DiseaseCellular transport and secretion