The Set1 Histone H3K4 Methyltransferase Contributes to Azole Susceptibility in a Species-Specific Manner by Differentially Altering the Expression of Drug Efflux Pumps and the Ergosterol Gene Pathway
Kortany M. Baker, Smriti Hoda, Debasmita Saha, Justin B. Gregor, Livia Georgescu, Nina D. Serratore, Yueping Zhang, Lizhi Cheng, Nadia A. Lanman, Scott Briggs
Abstract
Fungal infections are a major health concern because of limited antifungal drugs and development of drug resistance. Candida can develop azole drug resistance by overexpression of drug efflux pumps or mutating ERG11 , the target of azoles. However, the role of epigenetic histone modifications in azole-induced gene expression and drug resistance is poorly understood in Candida glabrata .
Topics & Concepts
AzoleBiologyErgosterolEffluxCandida glabrataMethyltransferaseHistone methylationDrug resistanceGene expressionMethylationGeneGeneticsBiochemistryDNA methylationMicrobiologyCandida albicansAntifungalAntifungal resistance and susceptibilityFungal Infections and StudiesPneumocystis jirovecii pneumonia detection and treatment