Photoredox-Catalyzed Three-Component Amidoheteroarylation of Unactivated Alkenes
Mengxuan Zhang, Ji Zhang, Yuchen Zhou, Yuxuan He, Jie Wu, Danqing Zheng
Abstract
A photoredox-catalyzed 1,2-amidoheteroarylation of unactivated alkenes with O -acyl hydroxylamine derivatives and heterocycles is presented. A range of heterocycles, including quinoxaline-2(1 H )-ones, azauracils, chromones, and quinolones, are capable for this process, allowing the direct synthesis of valuable heteroarylethylamine derivatives. Structurally diverse reaction substrates, including drug-based scaffolds, were successfully applied, demonstrating the practicality of this method.
Topics & Concepts
ChemistryQuinoxalineHydroxylamineCombinatorial chemistryCatalysisPhotoredox catalysisComponent (thermodynamics)Organic chemistryPhotocatalysisPhysicsThermodynamicsRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions