Subinhibitory Concentrations of Antibiotics Exacerbate Staphylococcal Infection by Inducing Bacterial Virulence
Peng Gao, Yuanxin Wei, Rachel Evelyn Wan, Ka Wing Wong, Ho Ting Venice Iu, Sherlock Shing Chiu Tai, Yongli Li, Hin Cheung Bill Yam, Pradeep Halebeedu Prakash, Jonathan Hon-Kwan Chen, Pak‐Leung Ho, Kwok‐Yung Yuen, Julian Davies, Richard Yi Tsun Kao
Abstract
exacerbated infection. The major highlight of this work is to prove the β-lactam and tetracyclines antibiotics exacerbated disease is due to their induction effect on staphylococcal virulence. This phenomenon is common and suggests that if β-lactam antibiotics remain the first line of defense during empirical therapy, we either need to increase patient reliability or the treatment approach may improve in the future when paired with anti-virulence drugs.
Topics & Concepts
AntibioticsVirulenceMicrobiologyBacteremiaTetracyclineBiologyIn vivoPeritonitisAmpicillinBiotechnologyGeneGeneticsBiochemistryBacterial Identification and Susceptibility TestingAntibiotic Resistance in BacteriaAntimicrobial Resistance in Staphylococcus