Design and synthesis of new series of chiral pyrimidine and purine analogs as COX-2 inhibitors: Anticancer screening, molecular modeling, and in silico studies
Aisha Y. Hassan, Eman S. Abou‐Amra, Samiha A. El‐Sebaey
Topics & Concepts
ChemistryPyrimidinePurineStereochemistryPurine analogueDoxorubicinIC50Cell cultureIn silicoIn vitroBiochemistryEnzymeChemotherapyInternal medicineBiologyGeneGeneticsMedicineSynthesis and biological activitySynthesis and Biological EvaluationInflammatory mediators and NSAID effects