Deep brain stimulation halts Parkinson’s disease-related immune dysregulation in the brain and peripheral blood
Rhonda L. McFleder, Thomas Musacchio, Johanna Keller, Susanne Knörr, Tobias Petschner, Jia Zhi Chen, Muthuraman Muthuraman, Mohammad Badr, Lisa Harder‐Rauschenberger, Fabian Kremer, Selin Asci, Sophie Steinhäuser, Ann-Kathrin Karl, Jonathan M. Brotchie, James B. Koprich, Jens Volkmann, Chi Wang Ip
Abstract
regulatory T cells. RNA-sequencing and immunohistochemistry in the brain of the A53T alpha-synuclein rat model of PD revealed that DBS also decreases neuroinflammation. These data suggest a potential disease-altering role for DBS by halting inflammatory processes.
Topics & Concepts
Deep brain stimulationMedicineNeuroscienceStimulationImmune systemPeripheralBrain stimulationParkinson's diseaseDiseaseImmune dysregulationPsychologyImmunologyInternal medicineNeurological disorders and treatmentsVagus Nerve Stimulation ResearchParkinson's Disease Mechanisms and Treatments