Reversed Immunoglycomics Identifies α-Galactosyl-Bearing Glycotopes Specific for <i>Leishmania major</i> Infection
Alba L. Montoya, Victoria Macleod Austin, Susana Portillo, Irodiel Vinales, Roger A. Ashmus, Igor L. Estevao, Sohan R. Jankuru, Yasser Alraey, Waleed S. Al-Salem, Álvaro Acosta-Serrano, Igor C. Almeida, Katja Michael
Abstract
caused OWCL. These glycotopes could prove useful in the development of rapid α-Gal-based diagnostics and vaccines for OWCL. Furthermore, this method could help unravel cryptic α-Gal-glycotopes of other protozoan parasites and enterobacteria that elicit the natural human anti-α-Gal antibodies.
Topics & Concepts
GlycanLeishmaniaBiologyTrypanosoma cruziAntibodyAntigenLeishmaniasisVirologyHeterologousImmunofluorescenceCutaneous leishmaniasisParasite hostingImmunologyMicrobiologyMolecular biologyGlycoproteinGeneBiochemistryWorld Wide WebComputer scienceResearch on Leishmaniasis StudiesTrypanosoma species research and implicationsToxin Mechanisms and Immunotoxins